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ID:387 Carbohydrate Deficient Transferrin (CDT)
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DescriptionAssay is not routinely available. This assay is only available to Bradford student medical practice. Contact Duty Officer to discuss.
IndicationTo discriminate between alcohol induced hepatotoxicity and liver disease of other origin.
Additional InfoThe majority of transferrin in the blood has 3-5 carbohydrate sidechains. CDT refers to transferrin with 0-2 sidechains, which usually represents <2.6% of the total. Alcohol inhibits glycosyl transferase and stimulates sialidase enzymes in the liver, resulting in an increase of CDT in the blood. More reliable indicator than GGT (more sensitive and much more specific) for recent heavy consumption of alcohol. Works best in males.
Concurrent Testsna
Dietary Requirementsna

InterpretationIf CDT present then patient has definitely been drinking. CDT remains in circulation for 7-14 days. CDT may be increased in advanced cholestatic liver disease due to reduced removal and in carbohydrate deficient glycoprotein syndromes.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesCDT result is expressed as a percentage of total transferrin.
Units%


IP Acute TAT5 days
IP Routine TAT5 days
GP Acute TAT5 days
GP Routine TAT5 days
Turnround CommentKevin Green:kevin.green@sth.nhs.uk / Laura.Price@sth.nhs.uk
Originally edited by : . Last edited on 22/11/2018 09:07:46. Published By SRG on 22/11/2017 09:07:46.