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Test and Tubes Database
ID:332 Porphobilinogen (PBG)
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DescriptionPorphobilinogen (PBG) is a pyrrole involved in porphyrin metabolism. It is generated by aminolevulinate (ALA) and the enzyme ALA dehydratase. PBG is then converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.
IndicationInvestigation of suspected acute porphyria and acute abdomen of unknown cause.
Additional InfoFor acute porphyrias collect samples when patients are symptomatic. Contact Dr JH Barth (via switchboard) or Dr M Henderson/Tim Degg ext 66861 or x66063. If urgent analysis is required please contact the duty biochemist or on-call duty consultant (via switchboard).
Concurrent Testsna
Dietary Requirementsna

InterpretationAn increased PBG excretion is diagnostic of acute porphyria. The specific diagnosis will require further tests (see additional info).

Ref. Range (Male) <0.9 umol/mmol creat
Ref. Range (Female)<0.9 umol/mmol creat
Ref. Range (Paed) <0.9 umol/mmol creat
Ref. Range Notes
Unitsumol/mmol (creat)


IP Acute TAT- Contact Laboratory
IP Routine TAT14 days
GP Acute TAT- Contact Laboratory
GP Routine TAT14 days
Turnround CommentNA
Originally edited by : . Last edited on 04/07/2019 08:34:07. Published By RB on 04/07/2018 08:34:07.