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ID:326 Hydroxyindole Acetic Acid (5-HIAA - plasma)
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DescriptionCarcinoid disease is characterised by tumours of the argentaffin cells which produce excessive amounts of serotonin. The serotonin is usually rapidly metabolised by the liver to 5-hydroxyindoleacetic acid which is excreted via the kidneys. However in mid gut tumours with liver metastases, or in foregut tumours where the serotonin drains directly into the systemic circulation, the serotonin can cause flushing, diarrhoea, wheezing and heart disease - the so called 'carcinoid syndrome'.
IndicationUsed in the investigation of carcinoid disease.
Additional InfoFasting sample required (all serotonin containing foods should have been avoided for at least 12 hrs prior to sample collection).
Concurrent Testsna
Dietary Requirementsna

InterpretationRaised levels may be indicative of carcinoid disease.

Ref. Range (Male)27-70 nmol/L
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesClinical Cut-off 118nmol/L
Unitsnmol/L


IP Acute TAT- Contact Laboratory
IP Routine TAT20 days
GP Acute TAT- Contact Laboratory
GP Routine TAT20 days
Turnround CommentNA
Originally edited by : . Last edited on 15/04/2020 17:08:53. Published By RB on 15/04/2019 17:08:53.