|ID:303 ||Tryptase (Mast Cell)||Search Links: General Info : Protocols : Patient Info|
|Description||Anaphylactic reactions (IgE dependant or non-IgE dependant) are mediated by the release of vasoactive mediators, including tryptase, from mast cells and circulating basophils. The investigation of anaphylactic reactions requires 3 serial samples (see collection conditions).|
|Indication||Suspected anaphylactic reactions and mastocytosis|
|Additional Info||Tryptase levels usually peak within an hour and has an in vivo half-life of 2.5 hours, returning to normal within 12-24 hours after release.
Plasma tryptase can be elevated in systemic mastocytosis. Here levels tend to be constantly raised. Mastocytosis is a rare disorder.|
|Interpretation||The presence of systemic mast cell degranulation is evidenced by an increase in serum tryptase however tryptase levels are persistently elevated in mastocytosis therefore random measurements are difficult to interpret.
Please contact the laboratory for interpretive advice on post mortem samples.|
|Ref. Range (Male)|
|Ref. Range (Female)|
|Ref. Range (Paed)|| |
|Ref. Range Notes||2 - 14|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|
Originally edited by : T.Bradley. Last edited on 14/09/2018 14:35:06. Published By AM on 14/09/2017 14:35:06.