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ID:256 11-Deoxycortisol (DOC)
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Description11-DOC is used in the differential diagnosis of congenital adrenal hyperplasia (11 beta hydroxylase deficiency). 11-DOC should be determined if a 46 XX virilized infant has normal 17OH-progesterone. 11-DOC is used as part of the metyrapone test as a measure of the pituitary-adrenal axis.
Indication
Additional Info
Concurrent Testsna
Dietary Requirementsna

Interpretation

Ref. Range (Male)6 - 22
Ref. Range (Female)6 - 22
Ref. Range (Paed)> 48 hr old : <20
Ref. Range NotesSpecifically elevated in 11B-hydroxylase deficiency (>100 nmol/l in neonates with 11-hydroxylase deficiency). 11-deoxycortisol can also be used to follow response to the metyrapone test for Cushings. It is measured at 09:00 hrs before and after test. A rise to over 1050 nmol/l suggests pituitary-dependant disease.
Unitsnmol/L


IP Acute TAT6 weeks
IP Routine TAT6 weeks
GP Acute TAT6 weeks
GP Routine TAT6 weeks
Turnround CommentNA
Originally edited by : JHB. Last edited on 27/10/2018 12:17:56. Published By Sylvia Bennett on 27/10/2017 12:17:56.