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ID:254 Systemic Sclerosis Antibody Profile
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DescriptionScleroderma (systemic sclerosis) is a complex disease associated with extensive fibrosis, vascular alterations and autoantibodies against various cellular antigens. There are two major subgroups: limited cutaneous scleroderma (lcSSc) (skin involvement limited to distal extremities) and diffuse cutaneous scleroderma (dcSSc) (symptoms diffusely distributed over trunk, distal and proximal extremities and the face). Scleroderma can also lead to dysfunction/failure of internal organs.
IndicationInvestigation of scleroderma/systemic sclerosis. This test in NOT indicated in patients who are either anti-centromere or anti-Scl-70 Ab positive on the ANA screen.
Additional InfoThis assay detects autoantibodies to 13 different scleroderma associated antigens: Scl-70, CENP A, CENP B, RP11 and RP155 (RNA polymerase III subunits), Fibrillarin, NOR90, Th/To, PM-Scl 100, PM-Scl 75, Ku, PDGFR (Platelet derived growth factor receptor) and Ro-52.
Concurrent TestsANA
Dietary Requirementsna

InterpretationAnti-Scl-70 Ab can be detected in up to 65% of patients with dcSSc. Anti-centromere Ab are most commonly associated with lcSSc and are detected in up to 82% of these patients. PM-Scl 100 and 75 Ab can be found on SSc and dermato-/polymyositis. The other autoantibodies are less prevalent in SSc. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesPositive/Negative
Units - Not Defined -

IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA
Originally edited by : AM. Last edited on 14/09/2018 14:34:32. Published By AM on 14/09/2017 14:34:32.