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ID:250 Myositis associated autoantibodies
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DescriptionIdiopathic inflammatory myopahies are an inflammatory disease of skeletal muscles. These myopathies can be divided into polymyositis, dermatomyositis, idiopathic myositis, anti-synthetase syndrome and overlap syndrome.
IndicationDermatomyositis, Polymyositis, idiopathic myositis, anti-synthetase syndrome, overlapping syndrome
Additional InfoThis assay detects autoantibodies to 11 different myositis associated antigens: Jo-1, Mi-2, Ku, PM-Scl100, PM-Scl75, SRP (signal recognition particle), PL-7, PL-12, EJ. OJ and Ro-52.
Concurrent TestsANA
Dietary Requirementsna

InterpretationAnti-Jo-1 Ab are found in polymyositis, often occur simultaneously in autoimmune diseases such as SLE, systemic sclerosis or interstitial lung fibrosis. Mi-2 Ab are highly specific for dermatomyositis. Anti- Jo-1, PL-7, PL-12 EJ and OJ antibodies are associated with anti-synthetase syndrome. Anti-SRP Ab is a marker for immune-mediated necrotising myopathy. Anti-PM-Scl 75 and 100 Ab are associated with overlap syndrome which manifests as a combination of polymyositis, dermatomyoitis and systemic sclerosis symptoms. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesPositive/Negative
Units - Not Defined -


IP Acute TAT- Contact Laboratory
IP Routine TAT14 days
GP Acute TAT- Contact Laboratory
GP Routine TAT14 days
Turnround CommentNA
Originally edited by : Anna McHugh. Last edited on 26/09/2019 11:31:15. Published By AM on 26/09/2018 11:31:15.