Trust Homepage > Pathology Homepage

Test and Tubes Database
ID:245 Cold Agglutinins
Search Links: General Info : Protocols : Patient Info

DescriptionUsed to demonstrate the presence of cold reacting autoantibodies. If antibodies demonstrated, a full thermal range test is performed. Antibodies detected are usually of the Ii blood group system, are IgM in class, are competent at complement activation but do not cause red cell lysis.
IndicationCold Haemagglutinin Disease (CHAD), Raynauds syndrome, mycoplasma pneumoniae, secondary cold autoimmune haemolytic anaemia.
Additional InfoThis test is now provided by the National Blood Service Reference Laboratory and MUST be requested by a consultant.
Concurrent TestsDirect Coombs Test, Full Thermal Range.
Dietary Requirements


Ref. Range (Male)Neat to 1 in 32 @ 4 C.
Ref. Range (Female)Neat to 1 in 32 @ 4 C.
Ref. Range (Paed) Neat to 1 in 32 @ 4 C.
Ref. Range Notes

IP Acute TAT- Contact Laboratory
IP Routine TAT- Contact Laboratory
GP Acute TAT- Not Available -
GP Routine TAT- Not Available -
Turnround CommentConsultant only request
Originally edited by : RJAR. Last edited on 03/11/2018 14:22:15. Published By RJAR on 03/11/2017 14:22:15.