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ID:225 Oligoclonal bands CSF
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DescriptionThe diagnosis of Multiple Sclerosis (MS) can be supported by the presence of oligoclonal bands in the CSF. The presence of IgG oligoclonal bands confined to the CSF (i.e. absent from a paired serum or with bands in addition to those found in a paired serum) is indicative of local immunoglobulin synthesis within the CSF.
IndicationDiagnosis of Multiple Sclerosis.
Additional InfoIn MS patients, plasma cells residing within the CNS secrete IgG immunoglobulins into to CSF. Serum immunoglobulins are also present in low concentration in the CSF. Isoelectric focusing is used to detect IgG oligoclonal bands within the CSF and serum. Both a serum and CSF sample must be run concurrently to assure that any bands detected in the CSF do not have origin in the serum (diffusion of serum bands into the CSF). The CSF and serum samples should be collected at the same time.
Concurrent TestsA paired serum gel samples is also required.
Dietary Requirementsna

InterpretationOver 90% of patients with clinically definite Multiple Sclerosis have CSF IgG Oligoclonal bands. However CSF IgG Oligoclonal bands are not specific for MS and have been described in many other disorders including various infective and inflammatory diseases of the CNS e.g. viral encephalitis, bacterial meningitis, neurosyphilis and SLE, however, in most of these diseases oligoclonal bands are uncommon.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesQualitative
Units - Not Defined -

IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA
Originally edited by : BD. Last edited on 14/09/2018 14:31:42. Published By AM on 14/09/2017 14:31:42.