|ID:214 ||Valproate||Search Links: General Info : Protocols : Patient Info|
|Description||Valproate is used in the treatment of absence seizures. It inhibits the enzymes gamma-aminobutyric acid transaminas (GABA) which results in an increased concentration of GABA in the brain. GABA is an inhibitor of pre and post synaptic discharges in the CNS.|
|Indication||Therapeutic Drug Monitoring.
|Additional Info||For an adult on a single dose of valproate the half life is 16 hrs but for an adult on chronic therapy the half life is only 12 hrs. PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 8 HOURS OF COLLECTION|
|Interpretation||Plasma concentration does NOT relate to anticonvulsant activity and their measurement can only be used as a measure of compliance. 90 - 95% of drug is protein bound hence low albumin levels and hepatic disease can increase levels of drug.|
|Ref. Range (Male)||See note|
|Ref. Range (Female)|| |
|Ref. Range (Paed)|| |
|Ref. Range Notes||Used only to check compliance.
NOTE: Reporting units changed from mmol/L to mg/L May 1, 2007
|IP Acute TAT||Refer to Website|
|IP Routine TAT||Refer to Website|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||Refer to Website|
Originally edited by : MC. Last edited on 24/05/2017 08:02:29. Published By Sylvia Mclellan on 24/05/2016 08:02:29.