Policy for Tests for Goodpasture's Syndrome

All samples requesting anti-GBM will be assayed by indirect immunofluorescence using monkey kidney.

GBM negative results are reported and no further action taken.

GBM positive samples are subsequently assayed by ELISA.

The ELISA test for anti-GBM autoantibodies is a semi-quantitative assay giving an indication of the level of antibody.

In specific cases where there is strong clinical suspicion of anti-GBM disease in the absence of antibodies detected by immunofluorescence, the ELISA may be carried out (by arrangement with the laboratory manager or consultant immunologist).

Refer also to the Policy on Urgent Samples.

Page updated: 01/01/11 | Updated by: Anna McHugh