Cellular Immunology Tests

For the detection and monitoring of Primary Immunodeficiency and Acquired Immunodeficiency (AIDS). All Patients with suspected primary immunodeficiency should be referred for an immunological opinion.

TEST
SAMPLE
TIME
COMMENTS
Lymphocyte function
 
 
BY PRIOR ARRANGEMENT ONLY
Lymphocyte subsets
5 ml EDTA
4 days
 
Neutrophil function
 
 
BY PRIOR ARRANGEMENT ONLY

Notes

1. Lymphocyte Surface Marker Analysis

Suspected primary immunodeficiency:
If possible, please ensure that a full blood count is performed simultaneously. With paediatric samples where volume is a problem, please send the above volume in EDTA to the laboratory where a full blood count can be arranged. All requests for lymphocyte surface marker analysis, other than for HIV monitoring, should be discussed with one of the medical consultants.

HIV monitoring:
Please ensure that a full blood count is performed simultaneously. Indicated in the investigation of immunodeficiency and monitoring of HIV infection. The use of CD4 counts as a surrogate marker for the diagnosis of HIV infection is unhelpful and constitutes poor medical practice. A low CD4 count is not diagnostic of HIV infection, occurring in a wide variety of other conditions viz primary immunodeficiency, viral and bacterial infection, lupus, steroid therapy.

2. Neutrophil Function

All patients requiring neutrophil function should be referred to the Consultant Immunologists for a clinical immunology opinion.

3. Functional Cellular Studies

All patients requiring functional assays should be referred to the Consultant Immunologists for a clinical immunology opinion.
Cellular functional assays are strictly by prior arrangement only.


Page updated: 28/10/2016 | Updated by: Anna McHugh

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