Voriconazole levels

Antifungal agents are assayed by liquid chromatography-tandem mass spectroscopy (LC-MS-MS). The results are highly specific and are not influenced by the use of antifungal combination therapy.

Use(s):

Confirmation of adequate levels and alerting to toxic levels in patients receiving voriconazole for treatment or prophylaxis of fungal disease.

Specimens:

Serum 250 µl minimum or 3 mL clotted blood

Results:

Drug concentration in mg/L, with advice on target levels. Trough levels should be maintained between 1 - 5.5mg/L.  If levels are below this: ensure dosing is appropriate in relation to meals (if given orally) - consider increasing dose or examining effects of concomitant medications.

95% Turnaround Time:

8 days

Note:

The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level similar to the cutoff for a therapeutic leve, ie 1.0mg/L , tested over 6 months yielded a mean 1.13 of mg/L and a standard deviation of 0.07, thus we estimate that 95% of all samples at this level will have a range from + or - 0.13 (1.96 x 0.07 ) mg/L.


Page Reviewed: 03/06/19 | Updated by: Kevin Roberts