Posaconazole levels

Antifungal agents are assayed by liquid chromatography-tandem mass spectroscopy (LC-MS-MS). The results are highly specific and are not influenced by the use of antifungal combination therapy.

Use(s):

Confirmation of adequate levels in patients receiving posaconazole for treatment or prophylaxis of fungal disease.

Specimens:

Serum 250 µl minimum or 3 mL clotted blood

Results:

Drug concentration in mg/L, with advice on target levels. Trough levels should be maintained above 0.7mg/L for prophylaxis and above 1.25mg/L for treatment. If levels are below this - ensure drug is taken with fatty food, consider increasing dose (max 800mg/d) or examining concomitant medications.

95% Turnaround Time:

8 days

Note:

The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level a similar level as the cutoff for a prophylactic level, ie 0.7mg/L , tested over 6 months yielded a mean of 0.99 mg/L and a standard deviation of 0.043, thus we estimate that 95% of all samples at this level will have a range from + or - 0.083 (1.96 x 0.043) mg/L.


Page Reviewed: 03/06/19 | Updated by: Kevin Roberts