Itraconazole Levels

Antifungal agents are assayed by liquid chromatography-tandem mass spectroscopy (LC-MS-MS). The results are highly specific and are not influenced by the use of antifungal combination therapy.

Use(s):

Confirmation of adequate levels and alerting to toxic levels in patients receiving itraconazole for treatment or prophylaxis of fungal disease.

Specimens:

Serum 250 µl minimum or 3 mL clotted blood

Results:

Drug concentration in mg/L, with advice on target levels.  Levels should be maintained above 0.5 mg/L. If levels are below this: ensure dosing is appropriate in relation to meals - consider increasing dose or examine effects of concomitant medications.

95% Turnaround Time:

8 days

Note:

The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level the same as the cutoff for a therapeutic level, ie 0.5mg/L, tested over 6 months yielded a mean of 0.59 mg/L and a standard deviation of 0.026, thus we estimate that 95% of all samples at this level will have a range from + or - 0.05 (1.96 x 0.026) mg/L


Page Reviewed: 02/07/19 | Updated by: Kevin Roberts