Itraconazole Levels

Antifungal agents are assayed by liquid chromatography-tandem mass spectroscopy (LC-MS-MS). The results are highly specific and are not influenced by the use of antifungal combination therapy.


Confirmation of adequate levels and alerting to toxic levels in patients receiving itraconazole for treatment or prophylaxis of fungal disease.


Serum 250 µl minimum or 3 mL clotted blood


Drug concentration in mg/L, with advice on target levels.  Levels should be maintained above 0.5 mg/L. If levels are below this: ensure dosing is appropriate in relation to meals - consider increasing dose or examine effects of concomitant medications.

95% Turnaround Time:

8 days


The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level the same as the cutoff for a therapeutic level, ie 0.5mg/L, tested over 6 months yielded a mean of 0.59 mg/L and a standard deviation of 0.026, thus we estimate that 95% of all samples at this level will have a range from + or - 0.05 (1.96 x 0.026) mg/L

Page Reviewed: 02/07/19 | Updated by: Kevin Roberts