For antibody tests, please send serum or clotted blood in a plain tube; EDTA blood is not suitable.
Use(s): Supportive evidence for endocarditis, osteomyelitis, endophthalmitis and systemic candidosis in immunocompetent patients.
Description: Determination of the presence and titre of precipitating antibodies to Candida albicans in serum. Sera are tested using countercurrent immunoelectrophoresis (CIE).
Specimens: Serum 500 µl minimum or 1 mL clotted blood.
Results: CIE: Negative, Positive (weak, neat, 1/2 – 1/64).
Interpretation: As Candida spp. are present as colonising or superficially infecting species in many, particularly hospitalised patients, interpretation of Candida antibody tests is always difficult. However, a strongly positive result ³ 1/16 in a patient with specific clinical signs, e.g. vegetations on a heart valve, provides supportive evidence for a diagnosis of in this case Candida endocarditis. Any titres less than this do not provide any evidence of systemic candidosis.
Mean Turnaround Times: Candida 4 days (90% in 6 days).