Aspergillus antibodies

For antibody tests, please send serum or clotted blood in a plain tube; EDTA blood is not suitable.

Use(s):

Diagnosis of allergic bronchopulmonary aspergillosis, aspergilloma, paranasal sinus aspergillosis, other forms of aspergillosis in immunocompetent patients.

Description:

Quantitation of IgG antibodies to Aspergillus fumigatus in serum using a commercial automated Fluorescent Immuno Enzyme Assay (ImmunoCAP).

Specimens:

Serum 300 µl minimum or 3mL clotted blood.

Results:

Results are returned as mg Antibody per litre (mgA/L) and range from <2.0 to >200.

Interpretation:

As Aspergillus fumigatus spores are common in the environment and almost everyone is exposed to them, low levels of antibody to A. fumigatus are found in many patients and are not clinically significant. However, the level of antibody which is considered significant is dependant upon the underlying conditions of the patient. In people with Cystic Fibrosis (CF) there are relatively higher levels of antibody to A. fumigatus compared to other patient groups; for CF patients levels of antibody >90 mgA/L are considered significant. In non-CF patients levels of antibody >40 mgA/L are considered significant.

Mean Turnaround Time:

10 days

Note:

The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level the same as the cutoff for a positive result (40mg/L), tested over 8 months yielded a mean of 49.95 mg/L and a standard deviation of 3.53, thus we estimate that 95% of all samples at this level will have a range from + or - 6.92 mg/L.

Link to further information.


Page Updated: 02/07/19 | Updated by: Kevin Roberts