Targets for Therapeutic Drug Monitoring

  Therapeutic Range in NEW (Mass) Units Conversion Factor to convert between Molar and Mass units
Caffeine 5 - 20 mg/L micromol/L x  0.2 = mg/L
Carbamazepine

4 - 12 mg/L  (monotherapy)

 

4-10 mg/L (combination therapy)

micromol/L x 0.236 = mg/L
Digoxin 0.5 - 1.0 microg/L nmol/L x 0.781 = microg/L
Lithium 0.4 - 1.0 mmol/L  
Paracetamol mg/L See BNF for toxicity mmol/L x 151 = mg/L
Phenobarbitone 10 - 40 mg/L micromol/L x 0.232 = mg/L
Phenytoin 10 - 20 mg/L micromol/L x 0.252 = mg/L
Salicylate mg/L See BNF for toxicity mmol/L x 138 = mg/L
Theophylline

10 - 20 mg/L (adult)

 

5 - 10 mg/L (neonate)

micromol/L x 0.180= mg/L
Valproate Useful for compliance only mg/L micromol/L x 0.144 = mg/L


Further information:

Contact Clinical Biochemistry (0113-39-23285, 0113-20-64293) or Medicines Information (0113-20-65377)

Note

  1. LTH changed reporting from molar to mass units in April 2007
  2. Digoxin therapeutic targets changed in December 2008

Reference

Hallworth M, Capps N. Therapeutic Drug Monitoring.. ACB Venture Publications 1993

 

Page updated: 02/09/09 | Updated by: Dr. Julian Barth