Water deprivation test 3: DDAVP Test

Procedure

Administer DDAVP 2 microgram im
Measure urine volume and osmolality at hourly intervals for at least 3 hours.

Fluid should be restricted to less than 500 mL in the 8 hours after the test

Contraindication

This test is contraindicated in patients with heart failure and ischaemic heart disease

Interpretation

see Water Deprivation Test #1

Sensitivity and Specificity

see Water Deprivation Test #1

References

• Thompson CJ. Polyuric states in man. Clin Endocrinol Metab 1989;3:473-497.
• Miller M, Dalakos T, Moses AM, Fellerman H, Streeten DHP. Recognition of partial defects in antidiuretic hormone secretion. Arch Intern Med 1970;73:721-729.