Biochemical Investigations in Laboratory Medicine
J H Barth, G E Butler & P J Hammond,
Clinical Biochemistry, Paediatric Endocrinology & General Medicine, Leeds General Infirmary & Harrogate General Hospital.
This new version of BILM was first posted in August 2008. There have been considerable changes and corrections from the first version and we are grateful to everyone who has helped. If you would like to be informed when updates and new pages are added, please register as a user.
Preface to first edition
Complex clinical problems usually require a spectrum of laboratory investigations initially to aid disease diagnosis and subsequently to monitor disease and treatment. This book has been designed to help choose the most appropriate tests for different clinical scenarios. These are approached with algorithms which should be used only as an guide for investigation as patients are individuals who do not take kindly to following rigid flow-charts.
Decision points on these algorithms are based on both clinical observations as well as laboratory tests. Some decisions require complex biochemical tests often requiring administration of inhibitory or stimulatory agents. These are described in protocols along with interpretative advice. Some protocols have absolute values for decision making which are based on assay methods employed by the laboratories at the Leeds Hospitals and can only be used as guidance for users of other laboratories.
We are very grateful to all our colleagues for their helpful advice and support and would particularly wish to thank Prof PH Bayliss, Mr AH Balen, Dr PE Belchetz, Dr MJ Henderson, Dr J Hooper and Dr SM Orme for their specific help with some of the more contentious areas of clinical investigation.
JHB, GEB, PJH